Effect of Ticagrelor Combined with Acupuncture on Myocardial Infarction and its Effect on Levels of Serum Myocardial Enzymes, Cytokines and T Lymphocytes

Abstract

To investigate the effect of ticagrelor combined with acupuncture on myocardial infarction and its effect on levels of serum myocardial enzymes, cytokines and T lymphocytes. 90 patients with myocardial infarction were equally divided into observation and control groups. The observation group was treated with ticagrelor combined with acupuncture, while the control group was treated with ticagrelor only. Hemodynamic indexes, left ventricular parameters, serum myocardial enzyme levels, cytokine levels and T lymphocyte levels were analyzed. The incidence of cardiovascular events 1 mo and 3 mo after treatment was investigated. There were no significant differences in heart rate, left ventricular end systolic diameter, left ventricular end diastolic diameter, intermittent septum thickness and posterior wall of left ventricle between two groups (p>0.05), while systolic blood pressure, diastolic blood pressure, mean arterial pressure and left ventricular systolic pressure in the observation group decreased and left ventricular end-diastolic pressure increased (p<0.05). After treatment, the levels of serum myocardial enzymes, tumor necrosis factor alpha, interferon gamma, interleukin-6, interleukin-17, interleukin-21 and interleukin-23 of observation group were significantly lower than control group, while transforming growth factor beta and T lymphocyte levels were significantly higher (p<0.05). The incidences of cardiovascular events in observation group were 2.22 % and 4.44 %, 1 mo and 3 mo after treatment, while it was 4.44 % and 8.89 %, respectively, in control group (p<0.05).