Abstract
(1). Although the importance of thyroid hormone in maintaining normal cutaneous structure and function is evident from the alterations in the skin in states of thyroid dysfunction, little is known of the precise effects of this hormone on the skin. It has been documented that thyroid hormone is necessary for the maintenance of normal hair growth (2). Eartly, Grad and LeBlond noted that mitotic activity and epidcrmal thickness were decreased when thyroideetomized rats were treated with thyroid hormone (3). The phosphatase activity of pigeon skin (4) and hexosamine content of dwarf mouse skin (5) is increased by thyroxine administration. Sparse and conflicting evidence exists on the effects of the thyroid on skin lipids. Abelin (6) reported an increase in cholesterol in hyperthyroid rat skin, but more recently it has been suggested that the increased rate of cholesterol synthesis in rat liver is not shared by the skin (7). The changes induced by experimental thyrotoxicosis in the metabolic activities of various tissues in vitro have been extensively studied.
Published Version
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