Abstract
A single injection of 0.020 U of thyrotropin (TSH) was given 2, 6, 12, 18 or 24 hr before autopsy to day-old chicks. The dry weight of the thyroids and the total thyroidal protein were significantly decreased by 2 hr after TSH stimulation. The total ribonucleic acid (RNA) in the thyroids was significantly increased by 12 hr after TSH administration. The 32P incorporation into the whole thyroid gland, the trichloroacetic acid (TCA) soluble, the ethyl alcohol soluble, the RNA and the TCA precipitate fractions of thyroids was increased by TSH treatment. The greatest and earliest increase was in the TCA soluble fraction, and, as 32P was lost from this fraction, it increased in the other fractions of stimulated glands. The 32P uptake into subcellular components such as nuclei, mitochondria and microsomes was significantly increased by at least 12 hr after TSH injection, but the 100,000 g supernatant of thyroids showed a significantly increased uptake by 2 hr after TSH. This was the most heavily labeled cellula...
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