Abstract
Androgen sensitive cells derived from the androgen responsive Shionogi 115 mouse mammary carcinoma, when cultured for 4 weeks in testosterone free medium lose their androgen responsiveness. Thyroid hormones influence this loss of steroid sensitivity especially if cells are cultured in medium supplemented with serum treated with AG1 × 10 resin which specifically removes thyroid hormones from it. These hormones slow down the loss of androgen responsiveness, maintaining the cells more responsive to the stimulatory effect of testosterone, without producing any detectable change in androgen receptor content. As the transition to androgen unresponsive status is accompanied in S 115 cells by profound changes in cell morphology, it is reasonable to hypothesize that thyroid hormones exert their effect through modifications of cell membrane properties.
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