Effect of thyroid dysfunction in gestation period on internal secretion of pregnant women and fetal complications

Abstract

Objective To investigate the effect of thyroid dysfunction in gestation period on internal secretion of pregnant women and fetal complications. Methods 138 patients with thyroid dysfunction in gestation period admitted into our hospital from January, 2014 to December, 2015 were selected as study objects. According to types of thyroid dysfunction, they were divided into a hypothyroid group (hypothyroidism, 74 cases) and a hyperthyroidism group (hyperthyreosis, 64 cases). And 50 pregnant women with normal thyroid function were selected as a control group. The levels of fasting plasma glucose (FBG), blood lipid [triglycerides (TG), total cholesterol (TC), high density cholesterol (HDL-C), low density cholesterol (LDL-C)] in all the groups were detected. The fetal complication was observed and compared. Results The levels of TG, TC, and HDL-C were higher and the FBG level was lower in the hypothyroid group than in hyperthyroidism group and the control group (P<0.05). The levels of TG, TC, and HDL-C were lower and the FBG level was higher in the hyperthyroidism group than in the control group (P<0.05). The levels of TG, TC, and HDL-C were higher in the subclinical hypothyroid group and the clinical hypothyroid group than in the hypothyroxinemia group (P<0.05). The incidence of fetal complications was 39.19% in the hypothyroid group and 35.94% in hyperthyroidism group, which were higher than that in the control group (16.00%) (P<0.05). Conclusions Hypothyroidism in gestation period will decrease patients’ blood glucose level and increase the levels of TG, TC, and HDL-C, while the blood glucose and lipid levels of hyperthyroidism in gestation period are opposite. Thyroid dysfunction in gestation period will increase the incidence of fetal complications. Key words: Gestation period; Thyroid dysfunction; Internal secretion; Complications