Abstract
Studies have shown that severe burns affect male fertility through hormonaldisequilibrium while similar cases in female are poorly understood. Therefore,in the present investigation we set out to study how third degree burn(TDB) disrupts ovarian histology and hormonal milieu. Fifteen adult femalealbino Wistar rats, weighs 150 – 200g were used in the experiment. Theywere divided in three groups (control, sham and experimental) containingfive rats in each group. TDB was induced on 30% of the total body surfacearea of experimental animals while the sham group had 30% of their totalbody surface area shaved and exposed to warm water at room temperature.The resulted observations showed that TDB cause significant decline in FSHlevels with elevation of prolactin; thereby altering the pituitary function viainterference in signaling pathway. It altered the stress center of brain, controllingsecretion of gonadotropin releasing hormone thus causing irregularityof the estrous cycle, delayed ovarian maturation and rapid degenerationof ovarian follicles.
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