Abstract
The effects of various thioamide derivatives on induction of ornithine decarboxylase ( L-ornithine carboxy-lyase, EC4.1.1.17) in rat liver were investigated. Among the thioamides tested, thioacetamide and acylthioureas, having less than 10 carbon atoms in the acyl group, were all effective in increasing enzyme activity in both normal and adrenalectomized rats. Induction of ornithine decarboxylase by thioacetamide was not affected by hypophysectomy, while that by acylthioureas, including hexanoylthiourea, was much less in the absence of the pituitary. When given together with growth hormone, hexanoylthiourea greatly amplified the action of growth hormone in increasing ornithine decarboxylase activity in hypophysectomized rats. This amplifying effect of hexanoylthiourea was also observed in normal rats. The elevation of ornithine decarboxylase activity by hexanoylthiourea was followed by increase in the levels of putrescine and spermidine in the liver.
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