Abstract
1. 1. We investigated the effect of the thiol reagent, thimerosal on calcium movements in the Jurkat T cell line. 2. 2. Thimerosal induced a rise in cytosolic Ca 2+ concentration due both to a release of Ca 2+ from intracellular stores and a Ca 2+ influx. 3. 3. Thimerosal, released Ca 2+ from the same intracellular stores than CD3 mAb and ionomycin. 4. 4. Emptying the Ca 2+ intracellular stores was accompanied by a marked decrease of phosphatidylserine synthesis indicating that phosphatidylserine synthesis occurs within or close to the endoplasmic reticulum Ca 2+-stores as previously described in CD3-, ionomycin- or Ca 2+-ATPase inhibitor-treated lymphocytes.
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