EFFECT OF THERAPEUTIC AND DOUBLE THERAPEUTIC DOSES OF IVERMECTIN ON OXIDATIVE STATUS AND REPRODUCTIVE HORMONES IN MALE RABBITS

El-Far El-Far

doi:10.3844/ajavsp.2013.128.133

Abstract

To investigate the biochemical alterations of oxida tive status and male sexual hormones, thyroid hormo nes, cortisol, liver function and kidney function; sixty male New Zealand White rabbits were equally allott ed according to their body weight into two groups. Con trol samples were collected before subcutaneous injection of rabbits by ivermectinin Therapeutic (T D) and Double Therapeutic Doses (DTD). After injection blood samples were collected from ear vein at 1 st , 3 rd and 7 th day of experiment and subjected to the biochemical analysis of urea, uric acid, creatinine , aspartate transaminase, alanine transaminase, lac tate dehydrogenase, creatine phosphokinase, triiodothyro nine, thyroxin, nitric oxide, total antioxidant cap acity, cortisol, testosterone and free testosterone. The o btained data of both TD and DTD revealed a significant increase in urea, uric acid, creatinine, aspartate transaminase, alanine transaminase, lactate dehydro genase, creatine phosphokinase, triiodothyronine, thyroxin, nitric oxide, cortisol, testosterone and free test osterone while total antioxidant capacity levels were signif icantly decreased. From the date data of the curren t study on TD and DTD with a higher value in the DTD. We can conclude that ivermectin induced deleterious effects on kidneys and hepatic functions, oxidative stress, we ight loss and increased testosterone and free testo sterone.

Highlights

Helmint infestations had been a persistent and major constraint on the performance and reproduction of the domestic animals
After injection blood samples were collected from ear vein at 1st, 3rd and 7th day of experiment and subjected to the biochemical analysis of urea, uric acid, creatinine, aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatine phosphokinase, triiodothyronine, thyroxin, nitric oxide, total antioxidant capacity, cortisol, testosterone and free testosterone
The obtained data of both Therapeutic Dose (TD) and Double Therapeutic Dose (DTD) revealed a significant increase in urea, uric acid, creatinine, aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatine phosphokinase, triiodothyronine, thyroxin, nitric oxide, cortisol, testosterone and free testosterone while total antioxidant capacity levels were significantly decreased

Summary

Introduction

Helmint infestations had been a persistent and major constraint on the performance and reproduction of the domestic animals. These infestations are chronic and debilitating in their effect causing huge economic losses. Five AVMs namely Abamectin (ABM), Ivermectin (IVM), Eprinomectin (EPR), Doramectin (DOR) and Emamectin (EMA) are widely as treatment of a broad spectrum of parasitic diseases (Giannetti et al, 2011). IVM is one of the most effective and widely used antiparasitic agents of broad-spectrum activity against numerous endoparasites and ectoparasites, especially nematodes and arthropods (Chaccour et al, 2013). IVM exhibits a broad spectrum of activity against gastrointestinal and lung nematodes as well as against ectoparasites of clinical relevance in domestic animals (Suarez et al, 2013). Paralysis of somatic muscles is associated with GABA-gated chloride channel receptors (Yovany et al, 2010)

Results

Discussion

Conclusion