Abstract
<p class="Abstract">This study deals with the utilization of photosensitizer (λmax ~ 660 nm) from the group of the phthalocyanines, in photodynamic therapy. Effect of the zinc phthalocyanine photosensitizer mediated photodynamic therapy was evaluated in vitro on the tumor cell line – HeLa (cervical cancer cells) using mass spectrometry and atomic force and fluorescent microscopy techniques.</p>
Highlights
Photodynamic therapy (PDT) is a promising treatment of neoplastic and non-neoplastic diseases
Atomic force microscopy: The AFM analysis was performed on HeLa cell treated by 5 Jcm-2 ZnPc PDT using Bruker Bioscope Catalyst atomic force microscopy
Fluorescent confocal microscopy: The visualization of the changes in the cytoskeletal actin structure of the on HeLa cells exposed to the 5 Jcm-2 ZnPc PDT was performed using fluorescent confocal microscopy
Summary
Photodynamic therapy (PDT) is a promising treatment of neoplastic and non-neoplastic diseases. PDT is widely used for treating tumors on the surface of skin or body cavity, including skin tumors, head and areas of the head. This therapeutic approach involves the administration of a tumor-localizing photosensitizer (PS) by intravenous injection or external application, and the subsequent targeted activation of this photosensitizer by exposure to light of a specific wavelength. All amino acid residues of a protein are subject to attack by hydroxyl radicals produced by ionizing radiation; Tyr, Phe, Trp, His, Met and Cys residues are the preferred targets.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
