Effect of the Use of GnRH Analogs in Low-Grade Cerebral Glioma

Abstract

Low-grade gliomas are children’s most common brain tumors, presenting a wide range of clinical, histological, and biological behavior. Estrogens and progesterone are steroid hormones. In recent years, there has been speculation about its relationship with its role in the development of tumors. We describe the case of a 2-year-old girl with a low-grade brain tumor treated with chemotherapy without changes in its measurements. Initiated treatment with Decapeptyl® due to precocious puberty presents a decrease in its solid component, more than 50% of the initial size three years after starting treatment. Various studies have described the influence of estrogen and progesterone on the development of gliomas, decreasing or increasing their expression in those tumors of greater aggressiveness, respectively. Despite the study of the tumor-hormonal expression relationship in other types of tumors, in brain tumors, its role in their treatment remains to be known.