Effect of the treatment with salve of topical tintir castor bark extract (jatropha multifida l) on the number of fibroblast, fibrin formation, and density of collagen in the wound healing process of the rat with the acute injury model

Abstract

The use of tradisional medicine in indonesia is part of the culture of the nation and much utilized by society. This study aimed to determine the effect of of  the Treatment With Salve Of Topikal Tintir Castor Bark Extract (Jatropha Multifida L) on the Number of  Fibroblast, Fibrin, Formation, And Density of Collagen In The Wound Healing Process of The Rat With The Acute  Injury  Model  through excision diameter of 0.8 cm x 0.8 on the rat back. The research was conducted in the Animal laboratory of Hasanuddin University and the Education Animal Clinic(KHP), UNHAS. The method used in this research is the post-test control group design only. The sample consisted of 45 Wistar rats were divided into 3 groups: negative control (Vaseline), positive control (Oxcytetracilin 3%) and extract stem tintir distance. Data analysis using one way test anova. The study results indicated that on day 3(tree) the fibroblast showed an significant differences between groups of negative group and the tintir castro stem group of 10% (p=0.081) and there was an significant between the positive group and the tintir castro stem group of 10% (p=0.167); and on day 7(seven) and day 14, there was a difference but significant.