Abstract
The present study further investigates certain androgen specific and nonspecific responses in mouse liver. The hepatic cytochrome P-450-dependent ethylmorphine N-demethylase system of androgen-insensitive (Tfm/Y) mice and normal littermates was evaluated in response to sex steroids, phenobarbital, and 3- methylcholanthrene. Microsomes from normal male (+/Y) mice had the greatest level of cytochrome P-450, but exhibited a lower Vma]t and higher Km for ethylmorphine N-demethylation than normal female (+/+), carrier female (Tfm/+), and Tfm/Y mice. Androgen treatment decreased ethylmorphine N-demethylase activity of +/+ and +/Y mice but had no effect in animals with a defective androgen receptor (Tfm/Y). By contrast, estradiol decreased activity in both Tfm/Y and +/Y mice. Cytochrome P-450 content was decreased by testosterone only in +/+ mice whereas estradiol decreased levels in all mice. The progestins, cyproterone acetate and progesterone, increased N-demethylase activity and cytochrome P-450 content in a...
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