Abstract
The goal of our study was to examine the effect of feed supplement Humilid on the antioxidant defense system, free radical processes, and histomorphological changes in the tissues of rats affected by Chromium (VI). Rats were divided into 4 groups. Animals of groups D2 and D3 received Humilid in a dose of 2 ml per kg of body weight for 28 days. From the 14th day of the experiment, rats of groups D1 and D2 were injected by K2Cr2O7 in a dose of 2 mg Cr per kg of body weight daily for 14 days. Control animals were injected with saline solution for 14 days. Results showed that Cr (VI) causes oxidative stress in rat tissues, accompanied by an increase in superoxide dismutase activity, lipid peroxidation products, and a decrease in glutathione peroxidase and glutathione reductase activity. Chromium also caused histopathological changes in the liver and kidney of rats. Watering of rats affected by Cr (VI) with Humilid leads to decreased oxidative processes, activation of the antioxidant defense system, and reduced pathological effects on animal tissues. Our results indicate the positive influence of Humilid on the rat’s organism, inhibiting free radical processes and exhibiting antioxidant, hepatoprotective, and adaptive properties.
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