Abstract

The effect of the physical structure and chemical modification of poly(glycol monomethacrylate) gels on the calcification of test implants has been studied. While the chemical modification of the poly(glycol monomethacrylate) backbone by the introduction of ionogenic groups did not affect the process of calcification, there was a substantial effect of the physical structure of the polymer, as determined by the monomer: water ratio, on the process of calcification of the implants. Homogenous and microporous gels showed calcification in the margin of the implant only exceptionally; in macroporous gels calcification occurred massively in the margin of the implant and in the case of a higher porosity in its centre. This phenomenon has been explained by the different degree to which the implant is penetrated by the newly formed tissue, as well as by the difference in accessibility of nutrition to the penetrating cells depending on the porosity of the implant.

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