Abstract
Resveratrol is the best-known chemical for extending the lifespan of various organisms. Extensive recent research has shown that resveratrol can extend the lifespan of single-celled organisms, but its effects on the extension of animal lifespans are marginal. Despite the limited efficacy of pure resveratrol, resveratrol with the endogenous property of the DJ rice in the resveratrol rice DJ526 previously showed profound health benefits. Here, we report that the resveratrol rice DJ526 markedly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 41.4% compared to that of the control. The resveratrol rice DJ526 also improved age-related symptoms such as locomotive deterioration, body weight gain, eye degeneration and neurodegeneration in D. melanogaster upon aging. This result shows the most significantly improved lifespan in animal experiments to date, meaning that the resveratrol rice DJ526 will assist in the development of a therapeutic agent for longevity or addressing age-related degeneration.
Highlights
Human aging occurs through the gradual deterioration of the body over time
We investigated the longevity effect of DJ526 callus induced from the mature seeds of the resveratrol DJ526 rice, demonstrating that the callus of the resveratrol rice DJ526 could extend the lifespan of Drosophila melanogaster [25]
The D. melanogaster maintained on the standard cornmeal media at 25 ◦ C were divided into five groups to transfer onto standard cornmeal media (Ctrl), cornmeal media supplemented with resveratrol (RS) media, cornmeal media supplemented with DJ rice (DJ), DJ media supplemented with resveratrol (DJRS), and cornmeal media supplemented with resveratrol rice DJ526 (DJ526) for laying eggs (Table S1), and the fly larvae were maintained in the media at 25 ◦ C
Summary
Human aging occurs through the gradual deterioration of the body over time. Naturally, this deterioration of the body makes aging the greatest risk factor for most human diseases [1,2]. addressing aging has been the primary scientific pursuit of modern health care, there is not much progress in understanding the aging process and anti-aging management. Human aging occurs through the gradual deterioration of the body over time. This deterioration of the body makes aging the greatest risk factor for most human diseases [1,2]. Resveratrol (3, 5, 40 -trihydroxy-trans-stilbene) is a polyphonic bioflavonoid phytonutrient and an antioxidant produced by plant roots and fruits [3,4]. The identity of resveratrol has been well known for decades, the compound did not receive scientific attention until it was shown to extend the lifespan of Saccharomyces cerevisiae by stimulating the silent information regulator (Sir) [5,6,7,8]
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