Abstract
Entamoeba histolytica synthesizes a heat-stable pentapeptide, originally identified by one of its effects on mononuclear phagocytes (MP) as a monocyte locomotion inhibitory factor (MLIF). In addition to several other in vitro measurable antiinflammatory actions, MLIF was also found in vivo to delay the arrival of the late mononuclear leukocyte component in Rebuck human skin windows (1), and to inhibit the 1-chloro-2-4-dinitrobenzene (DNCB) contact hypersensitivity skin reaction in guinea pigs, a predominantly late mononuclear leukocyte inflammatory animal model (2). To explore whether MLIF also affects the regulation of cell-adhesion molecules (CAMs), we chose to measure the monocyte integrin VLA-4 and its corresponding endothelial ligand, the Ig superfamily VCAM-1, an interaction couple essential for the rolling, adhesion, and eventual extravasation of monocytes (3,4) in the course of a DNCB contact hypersensitivity skin reaction in guinea pigs.
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