Abstract
Conventional suppositories were prepared by using polyethylene glycol (PEG) alone, and sustained-release suppositories were prepared by using hydroxypropylmethylcellulose phthalate (HP55) -PEG 1000, 2000 and 4000 matrices. The effect of the molecular weight of PEG on the in vitro release characteristic and bioavailability in rabbits of indomethacin (IM) in those suppositories was investigated. The release rate of IM from the conventional and matrix suppositories decreased slightly with increase of the molecular weight of PEG. The bioavailability of the conventional suppositories was independent of the molecular weight of PEG, but the bioavailability of the matrix suppositories decreased with increase of the molecular weight of PEG.
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