Abstract
Melatonin, the pineal gland hormone, has been considered as a central hypotension factor. However their roles in the regulation of the human blood pressure and its possible use as antihyper-tensive drug have not been fully determined. The objective of this trial was to determine the effect of melatonin on blood pressure morning increase and a peripheral vasoconstriction challenge in healthy volunteers. Twelve healthy male volunteers were included in a prospective, comparative, randomized, crossover trial in which changes on blood pressure (BP) and heart rate (HR) after the first morning orthostatism and endovenous norepinephrine (NE) infusion were measured one hour after the administration of placebo (PL) or 10 mg of melatonin in double blind conditions. Melatonin blunted the effects of the first orthostatism on BP and HR. Melatonin also reduces the pressor effect of NA. One concludes that melatonin has central and peripheral hypotensive effects that support a potential role of this hormone in cardiovascular therapeutics.
Highlights
Melatonin is the major pineal secretion; it has been related to blood pressure control and in several experimental [1] [2] and clinical trials it has demonstrated antihypertensive effects [3] [4]
Because it is necessary to evaluate the effect of the hormone on the blood pressure morning surge and on the norepinephrine pressor effect in order to determine the level of the antihypertensive actions of melatonin in humans
The change of position induced an increase in systolic blood pressure increase (SBP) and DBP that reaches its maximum in the first measurement after standing; it was made between 30 and 45 seconds after orthostatism
Summary
Melatonin is the major pineal secretion; it has been related to blood pressure control and in several experimental [1] [2] and clinical trials it has demonstrated antihypertensive effects [3] [4]. Because it is necessary to evaluate the effect of the hormone on the blood pressure morning surge and on the norepinephrine pressor effect in order to determine the level of the antihypertensive actions of melatonin in humans
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