Abstract
The purpose of this study was to investigate the effect of the HXBM408 bacteria on the diversity of rat intestinal bacteria and the metabolism of soybean isoflavones. The control group was administered sterilized water and daidzein by gavage for 7 days. Conversely, the experimental group was administered HXBM408 solution and daidzein by gavage for 7 days. The content of the daidzein metabolite equol in rat feces in the experimental group was significantly higher than that in the control group (P < 0.05) on the 7th and 14th days. However, the content of daidzein and its metabolites in feces was not significantly different (P > 0.05). On the 7th day, the relative abundance of Streptococcus in the feces of the experimental group was significantly higher than that of the control group (P < 0.05), but the difference disappeared over time (P > 0.05). In the intestinal digesta of rats, the proteobacteria of the experimental group was significantly lower than those of the control group (P < 0.05). HXBM408 can increase the degradation ability of soybean isoflavones in a short period after ingestion, increase the number of beneficial intestinal flora, and improve the structure of the flora.
Highlights
Soy isoflavones are polyphenolic compounds that have biological activities such as anti-cancer [1], menopausal syndrome relief [2], and cardiovascular disease protection [3]
Recent studies have shown that the biological activity of SIF with DAI as the main active ingredient is mainly attributed to the metabolites DHD and Eq that are degraded after being taken into the body, and the degradation process requires specific intestinal bacteria [13, 14]
SD rats were gavaged with the soy isoflavone-transforming bacteria HXBM408 isolated from fresh feces of pregnant horses
Summary
Soy isoflavones are polyphenolic compounds that have biological activities such as anti-cancer [1], menopausal syndrome relief [2], and cardiovascular disease protection [3]. After ingestion of soy isoflavones, animals can metabolize dihydrodaidzein (DHD), equol (Eq), and O-desmethylangolensin (O-Dma) under the action of specific bacteria in the gastrointestinal tract [4], these metabolites have higher biological activity than their parent compounds [5, 6]. Due to the differences in the structure of the gut microbiota among individuals, not all individuals have bacteria that can degrade soy isoflavones [7, 8].
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