Effect of the human albumin infusion speed on the hemodynamics in the liver cirrhosis patients with portal hypertension

Abstract

Objective To explore the suitable human albumin infusion speed in the liver cirrhosis patients with portal hypertension .Methods Fifty-eight portal hypertension patients need to infusion human albumin（50 ml,20%） were chosen and divided into the control group （n =30） and the experimental group （ n=28） by using the coin toss method .The control group received the infusion speed of 25 gtt/min for 45 min, and the experimental group received the infusion speed of 33 gtt/min for 30 min.The portal vein inside diameter （Dpv）, mean blood flow velocity （Vpv）, blood flow volume （Qpv） and the portal vein pressure measured by the color doppler ultrasound diagnostic instrument were compared at different times between two groups .Results At the end of the infusion, the Dpv,Vpv,Qpv and the portal vein pressure in the control group were （13.03 ± 2.01）mm,（9.40 ±2.06）cm/s,（782.29 ±313.02）ml/min and （2.747 ±0.348）kPa respectively, compared with the experimental group, and the differences were not statistically significant （t=-0.04,0.81,0.46,0.55, respectively;P〉0.05）.Conclusions It is feasible to input 10 g human albumin （50 ml,20%） during 30 min for the portal hypertension patients . Key words: Liver cirrhosis; Portal hypertension; Human albumin; Infusion speed; Homodynamic