Abstract
The leading place in the structure of general injuries and among facial injuries occupy fractures of the upper and lower jaws. An important factor in the occurrence of complications is the microbial factor, but the concomitant pathology, such as hepatobiliary diseases, is commonly associated with about 70% of the population. The purpose of the work was to study the features of reparative regeneration of the defect of the mandible in the pathology of the hepatobiliary system on the background of the administration of Forkal in the animal experiment. An experimental study was conducted on 100 white male Wistar rats weighing 240-270 g, aged from 5 to 6 months. During the work, the rats were divided into 5 groups: control (20 rats, in which histological changes of the bone tissue of the mandible of healthy rats with mandibular injury at the site of defect were investigated); experimental No. 1 (20 rats in which histological changes of mandibular bone tissue were studied at the site of defect at obstructive hepatitis, which was obtained by ligation and intersection of the common bile duct); experimental No. 2 (20 rats in which histological changes of bone tissue of the mandible were examined at the site of the defect in toxic hepatitis, which was obtained by administering per os four carbon monoxide); experimental No. 3 (20 rats in which histological changes of the bone tissue of the mandible were examined at the site of defect in obstructive hepatitis, which were obtained by ligation and intersection of the common bile duct, and then added Forkal); experimental No. 4 (20 rats in which histological changes in the bone tissue of the mandible of rats at the site of the defect in toxic hepatitis were studied, which was obtained by introducing per os four carbon monoxide, and subsequently added to Forkal). All rats were injured in the mandible with a standardized defect. In the future, we observed the histological signs of healing the area of the perforation defect. It was established that regeneration of the area of the defect of the mandible is worsening in the conditions of the experimental pathology of the hepatobiliary system: the rate of recovery of the specific volume of fibroreticular tissue during obstructive hepatitis is slowed down by 2.6 times and 3.4 times in the course of toxic hepatitis. With the use of Forkal in conditions of experimental pathology of the hepatobiliary system, the rate of regeneration of the defect site of the mandible improves and accelerates. Thus, in order to accelerate the rate of recovery of the specific volume of fibroreticular tissue for patients with mandible trauma and associated pathology of the hepatobiliary system, it is advisable to use Forkal.
Highlights
An increase in the number of fractures of the mandible and facial injuries remains one of the topical issues of jawfacial traumatology the problem of the etiopathogenesis of complications
After the manufacture of histological preparations, 5 characteristics were taken into account: the specific volume of fibroreticular tissue in the center of bone regeneration (%), specific volume of blood vessels (%), specific volume of bone beams in the bone regeneration center (%), the number of osteoblasts in a certain area in the bone regeneration cell, specific volume
It was found that the specific volume of fibroreticular tissue at the center of bone regeneration on 7 day is dominant over other elements and is about 91.41%
Summary
An increase in the number of fractures of the mandible and facial injuries remains one of the topical issues of jawfacial traumatology the problem of the etiopathogenesis of complications. Fractures of the upper and lower jaw occupy a leading place among facial injuries and in the structure of general injury. Injuries of jaw-facial area make up about 15-38% among all Effect of the Forkal on histologi cal changes of the rat's mandi ble bone tissue in the area of the traumatic. Along with the increase in the total number of injuries, an increase in the frequency of jawfacial injuries and their complications is observed, which is especially relevant with a steady increase in the number of patients with concomitant pathology [1, 3, 5, 6, 7, 8, 11, 12, 19, 20]. Most commonly observed: bone marrow suppuration, posttraumatic osteomyelitis, false joint, pathological motion of bone fragments, secondary hemorrhage, post-traumatic sinusitis or neuritis, bite violation [2, 17, 9, 12, 15, 20]
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