Abstract
Objective: to assess the features of the expression of the epithelial marker E-cadherin in the epithelial layer and stroma of the small intestinal mucous membrane after the administration of the food additive E407a.Materials and methods. E-cadherin expression was studied by the immunohistochemical method in 8 WAG rats receiving daily the food additive E407a orally for a period of 2 weeks in the amount of 140 mg per kg of body weight, and 8 control animals.Results. It has been found that the administration of E407a leads to reduced E-cadherin expression in intestinal epithelial cells (0.037 ± 0.004 U versus 0.129 ± 0.021 U in the control group, p<0.0001) per unit of area (250 × 250 micron).> < 0.0001) per unit of area (250 × 250 micron).Conclusion. Ingestion of the food additive E407a leads to a change in the expression patterns of the epithelial marker E-cadherin, which may contribute to the disruption of the intestinal epithelial barrier.
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