Abstract

AbstractTo test the hypothesis that the endothelial glycocalyx layer (EGL) may play a crucial role in protecting the artery from excessive infiltration of low density lipoproteins (LDLs), LDL transport in a multilayer artery model with EGL was simulated numerically under steady state flow conditions. The results showed that the increase in EGL thickness caused a sharp decrease in LDL concentration in intima, suggesting that an intact EGL might be crucial in protecting the arterial wall from excessive lipid infiltration/accumulation, hence can spare the arterial wall from atherosclerotic disease.Keywordsendothelial glycocalyx layerlow-desity lipoprotein transportatherosclerosis

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