Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric Mixtures

Emese Pálovics,Dorottya Fruzsina Bánhegyi,Elemér Fogassy

doi:10.3390/chemistry2030051

Emese Pálovics, Dorottya Fruzsina Bánhegyi + Show 1 more

Open Access

https://doi.org/10.3390/chemistry2030051

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Abstract

This perspective is focused on the main parameters determining the results of crystallization of enantiomers or enantiomeric mixtures. It was shown that the ratio of supramolecular and helical associations depends on the eutectic composition of the corresponding enantiomeric mixture. The M and P ratios together with the self-disproportionation (SDE) of enantiomers define the reaction of the racemic compound with the resolving agent. Eventually, each chiral molecule reacts with at least two conformers with different degrees of M and P helicity. The combined effect of the configuration, charge distribution, constituent atoms, bonds, flexibility, and asymmetry of the molecules influencing their behavior was also summarized.

Highlights

The preparation of asymmetric compounds is one of the main goals of research, industry and medicine
The preparation of a given enantiomer is possible in several ways, for example by selective synthesis, which requires the separation of the chiral catalyst or the enantiomers of the racemic compound, and in which case a resolving agent may be required
We are confronted with the non-linear behavior [1] as well as the self-organization [2] of chiral compounds and their M and P helicity [3]

Summary

Introduction

The preparation of asymmetric (chiral) compounds (enantiomers) is one of the main goals of research, industry and medicine. The preparation of a given enantiomer is possible in several ways, for example by selective synthesis, which requires the separation of the chiral catalyst or the enantiomers of the racemic compound, and in which case a resolving agent (like a chiral catalyst) may be required. In our work [4,5] we proved that the result of non-linear processes of enantiomers, enantiomeric mixtures, and mixtures of diastereomers, taking into account the solvent and the crystallization time, depends on the eutectic ratio of the enantiomeric mixtures of the participating chiral compounds.

Results

Conclusion