Abstract
External treatment of human erythrocytes with the diazonium salt of sulfanilic acid does not inhibit the Mg 2+-dependent ATPase but does markedly inhibit the Ca 2+-stimulated ATPase activity. Inhibition of the (Na + + K +)-dependent activity is dependent upon the concentration of diazonium salt used. Treatment of membrane fragments does not irreversibly inhibit the (Na + + K +)-dependent ATPase even though the diazonium salt binds covalently to membrane components. However, the Mg 2+-dependent and Ca 2+-stimulated ATPase activities are irreversibly inhibited. ATP and Mg-ATP will completely protect the (Na + + K +)-dependent ATPase when present during treatment of membrane fragments with the diazonium salt, but only Mg-ATP will protect the Mg 2+-dependent ATPase from inhibition. The Ca 2+-stimulated ATPase activity is not protected.
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