Effect of the consumption of green tea extract during pregnancy and lactation on metabolism of mothers and 28d-old offspring

Ana Claudia Losinskas Hachul,Claudia Maria Oller do Nascimento,Patricia Oliveira Carvalho,Alexandra C. H. F. Sawaya,Lila Missae Oyama,Eliane Beraldi Ribeiro,Mayara Franzoi Moreno,Valter Tadeu Boldarine,Nelson Inácio Pinto Neto

doi:10.1038/s41598-018-20174-x

Ana Claudia Losinskas Hachul, Claudia Maria Oller do Nascimento + Show 7 more

Open Access

https://doi.org/10.1038/s41598-018-20174-x

Copy DOI

Abstract

The objective was to investigate the effects of the maternal consumption of the green tea extract during pregnancy and lactation on mothers and offspring metabolism. The female Wistar rats, on the first day of pregnancy until the end of lactation, was divided into groups: MC– received water and ME– received green tea extract (400 mg/kg body weight/day), both ingested control diet. After lactation, at day 28th post-partum, the mothers and pups from each mother were euthanized and composed the groups: FC– pup from mother received water and FE– pup from mother received green tea extract. The ME group increased IL-10/TNF-α ratio and IL-1β content in the mesenteric and IL-1β content in retroperitoneal adipose tissues, and decreased catalase activity. The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-α ratio in retroperitoneal, IL-10 and TNF-α content in gonadal, and IL-6 content in mesenteric adipose tissues. In summary, the maternal consumption of green tea extract associated with control diet ingestion during pregnancy and lactation altered the inflammatory status of mothers and 28d-old offspring. These data elucidate the effects of green tea during pregnancy and lactation on maternal and offspring metabolism.

Highlights

The objective was to investigate the effects of the maternal consumption of the green tea extract during pregnancy and lactation on mothers and offspring metabolism
The mean body weights (BWs) and delta weight of the mothers during pregnancy and lactation, and pups with 28 days old were similar among groups during all treatment (Fig. 1)
Mothers that consumed green tea extract demonstrated an increase in IL-10/TNF-α ratio and IL-1β in the mesenteric adipose tissue and a decrease in catalase

Summary

Introduction

The objective was to investigate the effects of the maternal consumption of the green tea extract during pregnancy and lactation on mothers and offspring metabolism. The female Wistar rats, on the first day of pregnancy until the end of lactation, was divided into groups: MC– received water and ME– received green tea extract (400 mg/kg body weight/day), both ingested control diet. The maternal consumption of green tea extract associated with control diet ingestion during pregnancy and lactation altered the inflammatory status of mothers and 28d-old offspring. These data elucidate the effects of green tea during pregnancy and lactation on maternal and offspring metabolism. In rats, investigated potential adverse effects of standardized heat-sterilized green tea catechins (GTC-H) on embryo-fetal development. The doses used did not affect intrauterine growth and survival fetal malformations or developmental and only the 2000 mg/kg/day dose promoted hair loss in different areas[12]

Objectives

Methods

Results

Conclusion