Abstract
The aqueous extract of Crinum glaucum was evaluated using guinea pig trachea and was observed to neither relax the spontaneous tone of the guinea pig trachea nor KCl-induced tone. It, however, produced a concentration-dependent relaxation of carbachol- and histamine- pre-contracted trachea. The relaxant effect of the extract on carbachol-induced tone was not inhibited by propranolol, but potentiated by glibenclamide, procaine, methylene blue and L-nitro argininemethyl ester (L-NAME) with a progressive decrease in the median effective concentration (EC50) values. The extract (5-40 mg/kg body weight/day) produced a rightward shift and a depression of the maximal effects (Emax) of the anaphylactic contractions of the trachea while the extract at 2mg/ml produced a complete inhibition of the contractions.The results of this study clearly showed that the aqueous extract of Crinum glaucum possesses spasmolytic and anti-spasmogenic properties on normal and sensitized trachea and this may account for its use in the treatment of cough, asthma, and convulsions in traditional medicine.Key words: Crinum glaucum, trachea, anaphylactic contractions, histamine, carbachol
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