Abstract

AbstractThe effect of fractions isolated from the aqueous extract of Verbascum flowers on protein biosynthesis was studied. A strong inhibitory effect of the aqueous extract on protein biosynthesis was demonstrated in isolated rat liver ribosomes. The saponin fraction was shown to be responsible for this activity and it was compared to commercial glycyrrhizic acid and its aglycon as the standard drungs. It was found that these compounds strongly inhibited the incorporation of [14C]leucine into proteins in vitro and that the target site for inhibition was the ribosome fraction from rat liver cells.

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