Abstract
1-Hexyl-2-(perfluoroalkyl)-1-iodoethenes, C n F 2 n+1 CH=CIC 6H 13(FnH6IE), with high biocompatibility and X-ray contrast ability, were investigated as additives and stabilizers in perfluorooctyl bromide (perflubron, PFOB)/egg yolk phospholipids (EYP) emulsions (90:4 w/v%), the fluorocarbon-based preparation presently best suited for diagnostic uses. These iodinated mixed fluorocarbon/hydrocarbon compounds, when used as additives in various amounts in PFOB emulsions (replacement of 3–30 w/v% of PFOB by FnH6IE), enhanced the radiopaque effect of the emulsions, which furthermore remained stable. Moreover, among the PFOB/FnH6IE/EYP emulsions tested, the 70:20:4 (w/v%) formulation led to fine and stable emulsions with an X-ray contrast effect in vitro twice as radiopaque as that of a PFOB/ EYP (90:4 w/v%) emulsion. When FnH6IE were introduced as stabilizers in molar ratio of 1:1 with EYP, the emulsions did not show any significant increase in particle size after aging for 3 months at 40°C.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
