Abstract

Earlier experimental data support the hypothesis that the atrial natriuretic peptide (ANP) is a potential mediator of glomerular hyperfiltration in diabetic rats. Several studies have shown that the renal hemodynamic and excretory responses to ANP are modulated by intrarenal angiotensin II. In the present study we investigated the effect of the angiotensin-converting (ACE)-inhibitor enalapril on plasma concentration of ANP and on glomerular filtration rate (GFR) both in normotensive diabetic rats and in diabetic rats with five-sixths renal ablation. We didn’t find a significant increase of plasma ANP in rats with moderate hyperglycemia. Treatment with enalapril significantly (p<0.05) decreased GFR both in control rats and in normotensive diabetic rats. Plasma concentration of ANP was significantly (p<0.001) decreased in five-sixths nephrectomized rats with diabetes mellitus by ACE-inhibiton. “Normalization” of plasma ANP in diabetic rats with renal ablation by enalapril treatment was positively correlated with a reduction of systolic blood pressure and with a decrease of body weight, while GFR.didn’t change under these conditions.

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