Abstract
Extract: This study was undertaken to evaluate the effect of thalidomide on oxygenation of maternal and fetal brain tissue. Oxygen availability (O2a) was determined Polarographically using acutely and chronically implanted Pt and AgCl electrodes. Partial pressure of oxygen (pO2) was measured polarographically in vitro from blood samples, and blood flow was determined in vivo by the hydrogen diffusion rate method. Thalidomide increased concentrations of O2a in the brain of adult guinea pigs and fetuses by an average of 33 and 200%, respectively. Simultaneously, jugular venous blood pO2 was increased, and arterial-venous (A-V) difference of O2 content, blood flow, and O2 consumption were decreased. Arterial blood pO2, pH and hemoglobin levels, body temperature, heart rate, and blood pressure were not affected by thalidomide. Niacinamide or hydrocortisone administered 30 to 60 min before the injection of thalidomide either decreased or prevented the thalidomide-induced response. Speculation: It is postulated that thalidomide (or its metabolites) decreases cellular oxygen consumption by interfering with intermediary energy metabolism, and that this in turn could lead to developmental anomalies of the organism.
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