Abstract
Context: Abutilon indicum and Mimosa pudica were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. Aims: The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The recipe were composed of whole plants from A. indicum and M. Pudica (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. Results: All doses of the extracts were showed significantly (p<0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (p<0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (p< 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (p< 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. Conclusion: The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.
Highlights
Diabetes mellitus (DM) is a group of chronic metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, often combined with insulin action, or both
The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats
A Thai folklore recipe consist with M. pudica (MAIYA-LAP) and A. indicum (KHOB-FUN-SRI) have been reported as being effective in diabetic treatment
Summary
Diabetes mellitus (DM) is a group of chronic metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, often combined with insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction and failure of various organs and systems.[1] Diabetes requires continuous medical care and patient self-management education in order to prevent acute complications and to reduce the risk of long-term complications.[2] Oral anti-diabetic agents are expensive, and have undesirable side effects or contraindications.[3] Diabetic patients often seek complementary therapy such as herbal medicines. In Thailand, several herbal medicines have been documented support as diabetic treatment.[4] Many Thai medicinal plants have been used as the traditional medicines for management of diabetes. A Thai folklore recipe consist with M. pudica (MAIYA-LAP) and A. indicum (KHOB-FUN-SRI) have been reported as being effective in diabetic treatment
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