Abstract
The effects of tetrodotoxin (TTX) and K + perfusion on extracellular DA concentration (DA ext) and extraction fraction (also known as relative recovery or E d) were studied using a method for quantitative microdialysis under transient conditions. TTX administered through the microdialysis probe decreased DA ext with no effect on E d. Perfusion with high K + increased DA ext, with no initial effect on E d. However, a decrease in E d was observed under prolonged depolarization. These data provide further evidence that E d may change over the course of drug administration. This method of quantitative microdialysis is a reliable means for measuring changes in DA ext independently of possible changes in microdialysis probe efficiency.
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