Abstract
Adrenal 17-hydroxycorticosteroid (17-OHCS) secretion was followed after injection of tetramethylammonium or potassium chloride. In unanesthetized dogs the adrenal venous blood was collected by a modification of the method of Satake and his co-workers and was analyzed for 17-OHCS by the method of Nelson and Samuels. The 17-OHCS secretion rate before injection was 0.03-0.29μg/kg/min. After injection of tetramethylammonium it increased markedly in all of 3 dogs and attained to 1.10-1.43μg/kg/min. After injection of potassium chloride it increased definitely in 2 of 3 dogs and attained to 1.14-1.73μg/kg/min.
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