Abstract
Abstract: The effect of tetanus toxin on the uptake and release of radiolabelled transmitters from slices prepared from substantia nigra (SN) and striatum of rats has been investigated. Tetanus toxin‐500–750 mouse lethal doses (MLD)‐injected into the SN 6 h before preparing the slices significantly reduced the calcium‐dependent, potassium‐evoked release of [3H]GABA. Endogenous GABA levels in the SN and [3H]GABA uptake by nigral slices were unaffected by pretreatment with the toxin. Injections of tetanus toxin (1000–2000 MLD) into the striatum significantly reduced the calcium‐dependent, potassium‐evoked release of [14C]GABA and also [3H]dopamine, but had no effect on the K+‐evoked release of [3H]5‐hydroxytryptamine or [14C]acetylcholine. It is concluded that tetanus toxin inhibits GABA release directly and not by interference with synthesis or inactivation processes.
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