Abstract
Estrogen, when administered to male mice of certain strains, will result in the appearance of spontaneous mammary carcinoma.1, 2, 3 The females of these strains ordinarily have a high incidence of spontaneous mammary carcinomas, which do not normally occur in the males. It has further been demonstrated that the incidence can be increased and the time of appearance of the mammary carcinoma hastened by the administration of estrogen to the females of these same strains.4 Recently, Lacassagne5 tested the effect of testosterone upon development of mammary carcinoma in females of a high incidence strain and noted no alteration from the controls. The dosages used, however, were small.It is the purpose of this communication to report the results of long term injections of testosterone propionate∗ upon subsequent development and growth of spontaneous mammary tumors in female mice with an extremely high incidence (95%).6Forty female mice of the C3H strain, born at approximately the same time, were kept under simil...
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