Abstract
The present work describes the synthesis, characterization, thermal analysis and physico-chemical parameters of 2-((4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)methylthio)-3-o-tolylquinazolin-4(3H)-one (PDI-H). The compound PDI-H is synthesized by using standard protocols; purity is monitored by using TLC and characterized by IR and NMR spectral techniques. The thermal behavior of PDI-H was studied by TGA and DTA techniques at a heating rate of 10°C/min in nitrogen atmosphere. Thermal stability and kinetic parameters were determined according to the Freeman–Anderson method. The density (ρ), viscosity (η) and ultrasonic velocity (U) of pure solvents (chloroform (CF), N,N-dimethyl formamide (DMF)) and solutions of PDI-H (0.01–0.001M) in CF and DMF were investigated at three different temperatures: 303K, 308K and 313K. Using ρ, η and U data various thermodynamic parameters such as adiabatic compressibility (κa), intermolecular free path length (Lf), Rao's molar sound function (Rm), Van der Waals constant (b), internal pressure (π), free volume (Vf) and solvation number (Sn) were calculated. The results obtained were interpreted in terms of solute–solvent and solute–solute interactions. The structure making or structure-breaking abilities of the solute in CF and DMF solvent were also studied.
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