Effect of telmisartan on blood glucose levels in euglycemic albino rats

Abstract

Introduction: Diabetes is considered primary risk factor for heart disease and comorbidities in older people and in children. Due to escalating epidemic, diabetes is concerned high profile public health problem. Materials and Methods: Swiss albino rats weighing around 150-200gms of either sex were randomly selected from the central animal facility. Animals were randomly divided into 2 groups, six animals in each group. A group of 3 rats were kept in individual cages. The control was given 0.5 ml 1% Gum acacia, test group was given Telmisartan at the dose of 7.2mg/kg/day. All the drugs were given orally and for the period of 5 days. All rats were fasted overnight before the 5th day. On the 5th day glucose (0.6gm/kg body weight) was given orally using oral feeding tube and oral glucose tolerance test (OGTT) was performed. Blood was collected by tail snipping method and capillary blood glucose was assessed at 0, 60, and 150 minutes using a glucometer. Results: Fall in capillary blood glucose level was seen in Telmisartan group at all-time intervals when compared to control group. Conclusion:Telmisartan when given orally for 5 days showed fall in blood glucose level in swiss albino rats. Keywords: Adipokines, Capillary blood glucose, Diabetes, Euglycemic