Abstract
We examined the effects of tea polyphenols on the activation process of human mature basophils by stimulation with Ca2+ ionophore A23187 or IgE receptor crosslinking. IL-4 was used to induce differentiation in human leukemia cell line KU812 into the morphological and functional human mature basophils used in this study. Among the tea polyphenols examined, (−)-epicatechin gallate (ECG) and (−)- epigallocatechin gallate (EGCG) inhibited degranulation caused by IgE receptor crosslinking as well as by A23187. Thus, our findings suggest that the effects of ECG and EGCG may act on signaling pathway which regulates degranulation in human basophils after the increase of intracellular Ca2+ concentration.
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