Abstract
PurposeIt has been reported that tea catechins increase energy metabolism, but their effect on resting metabolic rate (RMR) remains under debate. This study aimed to examine the effect of repeated intake of tea catechins on energy metabolism in the resting state in middle-aged men and women.MethodsA total of 30 middle-aged men and women [13 women; age (mean ± SD) 52 ± 4 years; BMI 21.9 ± 2.2 kg/m2] were recruited. A randomized, double-blind, crossover study was conducted using a tea catechin-enriched beverage (611 mg catechins, 88 mg caffeine) and a placebo beverage (0 mg catechins, 81 mg caffeine) as test beverages. After 2 weeks of continuous test beverage intake, fasting RMR and energy expenditure (EE) after the ingestion of test beverage were measured. Measurements of forehead temperature (proxy for core temperature) and skin temperature were also obtained simultaneously.ResultsAmong participants who underwent measurements, 26 (10 women; mean age 52 ± 4 years; mean BMI 22.1 ± 2.1 kg/m2) were analyzed. The EE increased significantly after ingestion of the tea catechin beverage compared with the placebo beverage (placebo treatment: 5502 ± 757 kJ/day; catechin treatment: 5598 ± 800 kJ/day; P = 0.041). No between-treatment differences in fasting RMR or the respiratory quotient were detected. In addition, the forehead and skin temperature did not differ significantly between the placebo and catechin treatments.ConclusionThis study revealed that continuous intake of tea catechins with caffeine for 2 weeks significantly increased EE after ingestion of the tea catechin but not fasting RMR in middle-aged men and women.Clinical Trial Registry number and websiteThis trial was registered at www.umin.ac.jp/ctr/ as UMIN000025810 and UMIN000025811.
Highlights
Obesity and overweight are major global health problems and critical risk factors for diabetes and cardiovascular disease [1]
Three subjects with an activity level greater than 1.5 × the interquartile range above the third quartile during the fasting resting metabolic rate (RMR) and EE after ingestion of the test beverage measurement were excluded from the analysis; one subject who took medicine during the measurement periods was excluded and a per-protocol analysis was performed in twenty-six subjects
The findings of the present study demonstrated that repeated intake of a tea catechin with caffeine for 2 weeks significantly increased EE after ingestion by 96 kJ/day (6 kJ/90 min) compared with the placebo beverage in middle-aged men and women
Summary
Obesity and overweight are major global health problems and critical risk factors for diabetes and cardiovascular disease [1]. Weight gain is attributed to excessive energy intake, as represented by overeating or decreased energy expenditure (EE), or both [2, 3]. Tea catechins (polyphenols contained in green tea) are one of these plant-derived ingredients with the potential to improve energy balance [6]. Fasting RMR is known to decrease with age [14, 15], previous studies mostly targeted young healthy subjects to examine the effects of tea catechin with caffeine [8,9,10,11] and there are few studies describing the effects of tea catechin intake on fasting RMR and EE after ingestion in middle-aged individuals
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