Abstract
ObjectiveThe current research was directed for the estimation of hypoglycemic effect of taurine in alloxan-induced diabetic rats.MethodsTwenty-Four of female rats (<italic>Rattus norvegicus</italic>) were utilized for this purpose. Animals were further distributed in four groups having six rats in each group. Diabetes was induced by injected intraperitoneally with alloxan at single dose 125mg/kg body weight, group (1) (control group): animals of this group were treated only with distill water for 15 days, group (2) (diabetic group): animals of this group were injected intraperitoneally with alloxan at single dose 125mg/kg body weight, group (3) (taurine group): a 100 mg/kg body weight dose of taurine was intraperitoneally introduced for fifteen days, the group (4) (DM+taurine group): animals of this group intraperitoneally injected a single dose of (125mg/kg body weight) alloxan and after 7 days they were injected with taurine at a dose (100mg/kg body weight) for 15 days.ResultsA Significant upsurge (P≤0.05) was indicated in diabetic rats in the AST, ALT urea and creatinine’s levels. In addition, taurine supplementation caused a significant decrease in the levels of ALT, AST, urea and creatinine.ConclusionsTaurine Could have potential as a pharmaceutical drug for diabetes mellitus (DM).
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