Abstract
Breast cancer is the most frequent cause of cancer-related deaths in women. Large number of scientists report that 17β-estradiol promotes breast cancer cell proliferation, motility and invasion. However the detailed mechanism remains largely unknown. Metallopeptidase inhibitors, tissue inhibitors of metalloproteinases (TIMPs), are glycoproteins that are expressed in several tissues of organisms. The glycoproteins are natural inhibitors of matrix metalloproteinases (MMPs), a group of peptidases implicated in degradation of the extracellular matrix. In this study we investigated the effect of taurine on migration-related genes expressions in human breast cancer cells. Our results showed that the expressions of migration-related genes such as VEGF and MMPs were significantly stimulated by 17β-estradiol. On the contrary, taurine significantly blocked the expression of VEGF and MMPs against 17β-estradiol. In addition, taurine increased the expression of TIMPs which were suppressed by 17β-estradiol. We also demonstrated that taurine suppressed cell migration in a dose-dependent manner using Radius™ technology.
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