Abstract
This chapter reviews the stripping method and its application on the penetration enhancement into the stratum corneum (SC) and topical vaccination and defines restrictions and drawbacks. The SC is a permeability barrier that depends upon the presence of a unique mixture of lipids in the SC's intercellular domains. The composition and thickness of the SC lipids strongly differ depending on animal species. The major lipid classes in the SC are ceramides (CERs), cholesterol (CHOL), and free fatty acids (FFAs). Efforts have been undertaken to characterize the lipid lamellar regions. Diseases such as atopic dermatitis, psoriasis, and contact dermatitis are associated with barrier dysfunction. Diseases such as atopic dermatitis, psoriasis, and contact dermatitis are associated with barrier dysfunction. Percutaneous absorption and penetration is a complex physical and physiological process. The intercellular lipid domain is a major pathway for the permeation of most drugs through the SC and acts as a major barrier for penetration.
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