Abstract
Abstract Sleep bruxism (SB) is a sleep-related movement disorder characterized by grinding and clenchingof teeth during sleep. SB may cause tissue damage, temporomandibular disorders, and toothfractures if the strength and frequency of the bruxism is excessive. There is currently no treat-ment for SB. This report describes the cases of 6 patients who were prescribed tandospirone, apartial agonist of the 5-hydroxytryptamine (1A) receptor, to treat SB-related morning symptoms suchas morning orofacial jaw muscle fatigue and teeth-grinding sounds. Morning symptoms and teeth-grinding sounds were reduced or completely alleviated in all patients with SB after treatment withtandospirone. This study demonstrates the effectiveness of tandospirone for the treatment ofpatients with SB. Key words: sleep disorders, sleep bruxism, 5-hydoxytryptamine (5-HT) 1A receptor INTRODUCTION Sleepbruxism(SB)isasleep-relatedmovementdisordercharacterized by grinding and clenching of teeth duringsleep. 1 SBisaninvoluntarydisorderthatcanbedescribedasaparafunction.Althoughparafunctionsdonotdirectlycause biological tissue damage, movements of excessivestrengthandfrequencycanresultintemporomandibulardisorders (TMD) and tooth fractures. SB can result invariousconditions,includingexcessivetoothwear,toothfracture, muscle pain, gingival inflammation and reces-sion, TMD, and dental implant overload.
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