Effect of Tamsulosin Use on Plasma Insulin Status in Benign Prostatic Hyperplasia Patients in Sokoto, Nigeria

M Dikko,A.I Umar,A Chika,I.A Mungadi,S.O Bello,Y Sarkingobir

doi:10.4314/jasem.v24i4.1

Abstract

The objective of this paper was to determine the effect of tamsulosin use on plasma insulin status in benign prostatic hyperplasia (BPH) patients in Sokoto, Nigeria. Standard methods and procedures were used. At 2nd and 3rd months of tamsulosin use, there was a significant increase (P<0.05) in plasma insulin values compared to baseline. Likewise, at 4th month of tamsulosin use, a significant increase (P<0.05) in plasma insulin values was revealed compared to baseline and 2nd month values. Other inter-mean values comparisons were not significantly different (P>0.05). Plasma insulin at 4th months of the study in BPH patients (45-54 years) treated with tamsulosin revealed a significant increase (P<0.05) compared to baseline values. Other inter-mean values comparisons were not significantly different (P>0.05). BPH patients (aged 55-64 years) at 3rd month showed a significant increase (P<0.05) in plasma insulin values compared to baseline values. Likewise, at 4th month of tamsulosin use, a significant increase (P<0.05) in plasma insulin values was seen compared to baseline and 1st month values. Other inter-mean values comparisons were not significantly different (P>0.05). In BPH patients aged 65 and above, there was no significant difference (P>0.05) in plasma insulin values from 1st through 4th month compared to baseline and other inter mean values comparisons. Plasma insulin at 0th , 1st , 2nd , 3rd and 4th months of BPH patients of different age groups treated with tamsulosin revealed no significant differences (P>0.05). This study revealed that tamsulosin use in the patients lead to significant increase in plasma insulin level (hyperinsulinemia). Careful and routine monitoring of BPH patients should be done. Patients need enough exercise activities and some drugs can be administered to alleviate elevated glucose or insulin. Keywords: Tamsulosin, hyperinsulinemia, benign prostatic hyperplasia patients, insulin resistance

Highlights

Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTs) constitute a prevalent public health threat among older men in Nigeria
The objective of this paper was to determine the effect of tamsulosin use on plasma insulin status in benign prostatic hyperplasia (BPH) patients in Sokoto, Nigeria
Plasma insulin at baseline (0th) and at 1st, 2nd, 3rd and 4th months of the study in benign prostatic hyperplasia patients treated with tamsulosin: At 2nd and 3rd month of tamsulosin use, there was a significant increase (P

Summary

Introduction

Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTs) constitute a prevalent public health threat among older men in Nigeria. As tamsulosin is increasingly accepted, adverse drug reaction (ADRs) are emerging due to its usage (Lyseng-Williamson et al, 2002; Kang et al, 2009; Cooney et al, 2012; Dankner et al, 2012) These ADRs include skin rash, respiratory symptoms, constipation, vomiting, and visual problems; which are associated with hyperglycemia or hyperinsulinemia (Dikko, 2019). Diabetes is a condition defined by the level of hyperglycemia which inturn give rise to microvascular threats (such as nephropathy, neuropathy) and macrovascular problems (such as stroke, peripheral vascular disease,ischaemic heart disease). It is associated with significant morbidity, mortality and reduced quality of life (WHO, 2006). The objective of this paper was to determine the effect of tamsulosin use on plasma insulin status in benign prostatic hyperplasia (BPH) patients in Sokoto, Nigeria

Objectives

Methods

Results