Effect of Tablet Processing and Formulation Factors on Disintegration and Dissolution of Aceclofenac Tablets

Abstract

Aceclofenac, a non-steroidal anti-inflammatory drug, is used for posttraumatic pain and rheumatoid arthritis. The tablets were produced by simple wet granulation method. The post compressional parameters, hardness, friability, drug content of all the formulations were within the official limits. The disintegration time did not change with the type of diluents (mannitol, microcrystalline cellulose and dicalcium phosphate). However, it varied with the concentration of polyvinylpyrrolidone and microcrystalline cellulose. As the concentration of acacia was decreased, disintegration time decreased and hence, dissolution increased. Incorporation of superdisintegrants improved the disintegration time as well as dissolution of the drug. As the granules size increased disintegration time decreased and increase in dissolution was noticed. It can be concluded that the selection of combination of variables and levels were important in the optimization of aceclofenac tablet formulation.