Abstract
SummaryThree synthetic vitamin K compounds were administered to 26 patients with hypoprothrombinemia. Following treatment the prothrombin concentration: (1) was markedly elevated in 11 patients with obstructive jaundice, (2) was not elevated in 8 and only slightly elevated in 3 patients with chronic diseases of the liver; (3) was not elevated in 1 patient, and after an initial delay was elevated in 1 patient with acute diseases of the liver; (4) was moderately elevated in 2 patients, one with non-tropical sprue, and the other with gastro-colic fistula. When considered in terms of the dosages employed, there were no significant qualitative differences in the relative effectiveness of the three compounds. No untoward reactions were observed except that the patients receiving large doses of 4-amino-2-methyl-naphthol-hydrochloride complained of slight burning pain at the site of injection.
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