Abstract
SummaryLong-term administration of synthetic salmon calcitonin to rabbits markedly decreases the radioiodine (131I) uptake in the thyroid gland as well as in the plasma. Protein-bound iodine and thyroxine serum levels are also decreased. In contrast, the renal iodine clearance is much increased in calcitonin-treated rabbits as compared to controls or to vehicle alone. This ioduric effect of salmon calcitonin can explain its role in goiter induction.This study was supported in part by NIH-General Grant, and Detroit General Research Corporation. We thank the Armour Pharmaceutical Company for the kind supply of synthetic salmon calcitonin used in this study.
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