Abstract
The insertion of more than one open-end catheter into the lumen of the tube at preselected points, as well as in the myometrium and uterus, was the method used to record pressure changes in those areas. The same catheters were used to inject locally small amounts of drugs and observe their effects upon contractility. This is a new method to make pharmacologic observations upon the oviducts in situ. From the study of adrenergic drugs it may be concluded that: (1) Human tubes in situ (nonpregnant or in early puerperium) respond to the injection of norepinephrine in a biphasic manner by increasing the intraluminal pressure (stimulation) followed by a transient period of inhibition before complete recovery occurs. (2) These responses may be selectively blocked by α- and β-receptor-blocking agents, thus suggesting that they are mediated by this mechanism. (3) The β-receptor-stimulating agents are very effective in inducing relaxation. When injected in small amounts in tubes with a high base line, they may favor the appearance of normal regular patterns.
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